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3.3 Anticancer mechanisms of omega-3 fatty acids 3.3.1 Regulation of inflammatory pathways Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce the levels of pro-inflammatory cytokines and downregulate inflammatory mediators such as COX-2, TNF-α, NF-κB, and prostaglandin E2 (PGE 2 ), which attenuates cancer-related inflammatory responses (50, 51)